Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CGP 37849 是一种竞争性口服活性 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂((Ki = 35 nM)),具有有效性。CGP 37849 是啮齿动物的抗惊厥药,也具有抗抑郁和抗焦虑的特性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,550 | 现货 | ||
5 mg | ¥ 3,880 | 现货 | ||
10 mg | ¥ 5,580 | 现货 | ||
25 mg | ¥ 8,590 | 现货 | ||
50 mg | ¥ 11,500 | 现货 | ||
100 mg | ¥ 15,600 | 现货 |
产品描述 | CGP 37849 is a competitive orally active N-methyl-D-aspartate (NMDA) receptor antagonist ((Ki = 35 nM)) with potency.CGP 37849 is an anticonvulsant in rodents and also has antidepressant and anxiolytic properties. |
靶点活性 | Seizures:21 mg/kg(ED50), l-[3H]-glutamate:220 nM(Ki), [3H]-(±)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonate (CPP):35 nM(Ki) |
体外活性 | Within the hippocampal slice in vitro, CGP 37849 demonstrates reversible and selective antagonism against NMDA-induced increases in the firing rate of CA1 pyramidal cells. In the presence of a low Mg2+ level medium, concentrations of CGP 37849 up to 10 μM effectively inhibit burst firing evoked in CA1 neurons by stimulating Schaffer collateral-commissural fibers, while leaving the magnitude of the initial population spike unaffected.[1] |
体内活性 |
In vivo, oral administration to rats of CGP 37849 selectively blocks firing in hippocampal neurons induced by ionophoretically-applied NMDA, without affecting the responses to quisqualate or kainate.[1] Oral administration to mice of CGP 37849 suppresses maximal electroshock-induced seizures in mice with an ED50 of 21 mg/kg.[1] |
别名 | CGP-37849, CGP37849 |
分子量 | 209.14 |
分子式 | C6H12NO5P |
CAS No. | 127910-31-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 90.0 mg/mL (430.3 mM)
DMSO: Soluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 4.7815 mL | 23.9074 mL | 47.8149 mL | 119.5372 mL |
5 mM | 0.9563 mL | 4.7815 mL | 9.563 mL | 23.9074 mL | |
10 mM | 0.4781 mL | 2.3907 mL | 4.7815 mL | 11.9537 mL | |
20 mM | 0.2391 mL | 1.1954 mL | 2.3907 mL | 5.9769 mL | |
50 mM | 0.0956 mL | 0.4781 mL | 0.9563 mL | 2.3907 mL | |
100 mM | 0.0478 mL | 0.2391 mL | 0.4781 mL | 1.1954 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CGP 37849 127910-31-0 Membrane transporter/Ion channel Neuroscience NMDAR iGluR CGP-37849 CGP37849 Inhibitor inhibitor inhibit